Event Program
Join us for four days of research presentations and discussions on Fragile X Syndrome and neurodevelopmental disorders. Our program features keynote lectures, mini-symposiums, scientific sessions, and poster presentations, bringing together researchers from around the world.
Day 1 (Monday 15 Sept):
14:00 - 16:00
Hotel Check-In and Conference registration
16:00 - 16:15
Welcome introduction
16:15 - 17:15
Mini-symposium 1: Excitation/inhibition balance measurements in ASD and monogenetic conditions
Chair: Hilgo Bruining
Speakers: TBA
Chair: Hilgo Bruining
Speakers: TBA
17:15 - 18:15
Keynote Lecture 1: Ernest Turro
Discovery and characterization of RNU4-2 and RNU2-2-related disorders.
Discovery and characterization of RNU4-2 and RNU2-2-related disorders.
18:30 - 20:00
Welcome reception
20:00 - 22:30
3-course Dinner
Day 2 (Tuesday 16 Sept):
07:00 - 08:30
Breakfast
08:30 - 09:30
Mini-symposium 2: Sensory Hypersensitivity in Fragile X Syndrome and Autism
Chair: Elizabeth McCullagh
Speakers: Elizabeth McCullagh: “Potential common mechanisms underlying sensory alterations in mouse models of autism”
Andreas Frick: “Neural alterations in the neocortex underlie tactile perception changes in a mouse model of autism”
Alexander A. Chubykin: “FMRP Expression in interneurons partially rescues visual phenotypes in FXS mice”
Benjamin Auerbach: “Atypical sound processing in a rat model of Fragile X Syndrome”
Chair: Elizabeth McCullagh
Speakers: Elizabeth McCullagh: “Potential common mechanisms underlying sensory alterations in mouse models of autism”
Andreas Frick: “Neural alterations in the neocortex underlie tactile perception changes in a mouse model of autism”
Alexander A. Chubykin: “FMRP Expression in interneurons partially rescues visual phenotypes in FXS mice”
Benjamin Auerbach: “Atypical sound processing in a rat model of Fragile X Syndrome”
09:30 - 11:00
Poster Session 1 and Coffee break
11:00 - 12:30
Session 1: Genetics of Neurodevelopmental Disorders
12:30 - 13:30
Lunch and networking
13:30 - 15:00
Session 2: New pathways in FraX
15:00 - 17:00
Beach Volleyball and Sandcastle building
17:00 - 18:00
Mini symposium 3: Keep it balanced! The consequences of SETBP1 dosage alterations on brain development
Chair: Alessandro Sessa, Carl Ernst
Speakers :Alessandro Sessa: “Revealing SETBP1 functions through experimental modelling Schinzel-Giedion Syndrome”
Carl Ernst: “SETBP1 dosage syndromes and an Nof1 antisense oligonucleotiode clinical trial for Schinzel-Giedion Syndrome”
Meggie Wong: “Deciphering the neurobiological pathways involved in heterogenous SETBP1-haploinsuPiciency disorder using human brain organoids and transcriptomics”
Maria Chahrour: “Investigating the molecular mechanisms underlying SETBP1 haploinsuPiciency disorder”
Chair: Alessandro Sessa, Carl Ernst
Speakers :Alessandro Sessa: “Revealing SETBP1 functions through experimental modelling Schinzel-Giedion Syndrome”
Carl Ernst: “SETBP1 dosage syndromes and an Nof1 antisense oligonucleotiode clinical trial for Schinzel-Giedion Syndrome”
Meggie Wong: “Deciphering the neurobiological pathways involved in heterogenous SETBP1-haploinsuPiciency disorder using human brain organoids and transcriptomics”
Maria Chahrour: “Investigating the molecular mechanisms underlying SETBP1 haploinsuPiciency disorder”
18:00 - 19:00
Keynote Lecture 2: Lynne Maquat
19:00 - 20:00
Personal time
20:00 - 22:30
Dinner
Day 3 (Wednesday 17 Sept):
07:00 - 08:30
Breakfast
08:30 - 09:30
Mini symposium 4: Double-Blind, Placebo-Controlled Trial of Metformin in Individuals with Fragile X Syndrome (FXS)
Chair: Sarah Lippé
Speakers: Randi Hagerman, Sebastien Jacquemont, François Bolduc: “Mechanisms of Action, Safety, and Results of the Trial on Metabolism and Behavioral Measures”
Leonard Abbeduto: “Baseline Characteristics of Participants and Effects of Metformin on Language”
David Randal Hessl: “Baseline Characteristics of Participants and Effects of Metformin on Executive Functions”
Sarah Lippé: “Baseline Characteristics of Participants and Effects of Metformin on Brain Dynamics Measured by EEG”
Chair: Sarah Lippé
Speakers: Randi Hagerman, Sebastien Jacquemont, François Bolduc: “Mechanisms of Action, Safety, and Results of the Trial on Metabolism and Behavioral Measures”
Leonard Abbeduto: “Baseline Characteristics of Participants and Effects of Metformin on Language”
David Randal Hessl: “Baseline Characteristics of Participants and Effects of Metformin on Executive Functions”
Sarah Lippé: “Baseline Characteristics of Participants and Effects of Metformin on Brain Dynamics Measured by EEG”
09:30 - 11:00
Poster Session 2 and Coffee break
11:00 - 12:00
Session 3: Molecular basis of Neurodevelopmental Disorders
12:00 - 13:00
Lunch and networking
13:00 - 16:30
Naturalis Biodiversity Center
16:30 - 17:30
Mini-symposium 5: Cross-Species Insights into the Neural and Molecular Mechanisms of Autism
Chair: Ourania Semelidou
Speakers:Michael Hart: “Autism-associated gene function in C. elegans circuits and behaviors”
Kyriaki Foka: “Behavioral and molecular investigation of autism spectrum disorder using Drosophila models”
Anna Letizia Allegra Mascaro: "Modulating cortical dysfunction in Shank3 mice"
Ourania Semelidou: "Uncovering the neural basis of perceptual alterations in the Fmr1-/y mouse model of autism"
Chair: Ourania Semelidou
Speakers:Michael Hart: “Autism-associated gene function in C. elegans circuits and behaviors”
Kyriaki Foka: “Behavioral and molecular investigation of autism spectrum disorder using Drosophila models”
Anna Letizia Allegra Mascaro: "Modulating cortical dysfunction in Shank3 mice"
Ourania Semelidou: "Uncovering the neural basis of perceptual alterations in the Fmr1-/y mouse model of autism"
17:30 - 18:30
Session 4: Epigenetics in FXS and other Neurodevelopmental Disorders
18:30 - 19:30
Keynote Lecture 3
19:30 - 20:00
Personal time
20:00
Beach Dinner
Day 4 (Thursday 18 Sept):
07:00 - 08:30
Breakfast
08:30 - 09:30
Mini-symposium 6: ATR-X Syndrome and Related Disorders
Chair: Norifumi Shioda
Speakers: Norifumi Shioda: TBA
Takahito Wada: TBA
Richard Gibbons: “Understanding how ATRX mutations perturb gene expression”
David Picketts: “The chromatin remodeler ATRX regulates entorhinal cortex identity, laminar organization, and circuitry with the hippocampus”
Chair: Norifumi Shioda
Speakers: Norifumi Shioda: TBA
Takahito Wada: TBA
Richard Gibbons: “Understanding how ATRX mutations perturb gene expression”
David Picketts: “The chromatin remodeler ATRX regulates entorhinal cortex identity, laminar organization, and circuitry with the hippocampus”
09:30 - 10:00
Coffee break
10:00 - 11:30
Session 5: Clinical Studies & trials
11:30 - 12:15
Poster awards & Planning of next FXS-NDD meeting in 2027
12:15 - 14:00
Lunch and departure
Note: Private meeting room available whole day on Tuesday and Wednesday
Get In Touch
For questions about the 21st Workshop on Fragile X Syndrome & Other Neurodevelopmental Disorders, we're here to help.
You can reach us through the form or through our email.